Castration-Resistant Prostate Cancer (CRPC) Primary with Metastatic FFPE Tissue Block Pairs: A Powerful Research Resource

Discover CRPC primary with metastatic FFPE tissue block pairs including IHC results, Gleason score, treatment medication, and serum testosterone levels.

Introduction

Castration-Resistant Prostate Cancer (CRPC) represents a major clinical challenge in oncology. Despite androgen deprivation therapy (ADT), some patients experience disease progression, metastasis, and treatment resistance. To advance research, access to paired primary and metastatic prostate cancer FFPE tissue blocks with detailed clinical and pathological data is invaluable. ArraysBank provides CRPC primary-metastatic FFPE tissue block pairs, offering scientists high-quality materials for translational research, biomarker validation, and therapeutic development.

Key Features of CRPC Primary–Metastatic FFPE Tissue Block Pairs

Each set of paired formalin-fixed paraffin-embedded (FFPE) tissue blocks is pathologist-verified and annotated with rich clinical metadata, enabling robust scientific investigations.

• Primary tumor and matched metastatic lesion tissue blocks

• Immunohistochemical (IHC) results for key prostate cancer biomarkers

• Gleason Score & Gleason Grade for histopathological classification

• Treatment medication history (androgen deprivation therapy, chemotherapy, or novel agents)

• Serum testosterone concentration at recurrence or progression

• Reference range of castration level (e.g., <50 ng/dL, <20 ng/dL) for clinical correlation

This depth of annotation ensures meaningful research outcomes by linking tissue morphology to treatment history and clinical status.

Why Use Matched Primary–Metastatic Tissue Blocks?

Working with primary–metastatic pairs provides unique scientific insights not possible from single tumor samples:

• Disease progression analysis – Study the molecular and morphological changes from primary prostate tumors to metastatic lesions.

• Therapy resistance mechanisms – Correlate pre- and post-treatment IHC profiles with serum testosterone levels and castration thresholds.

• Biomarker validation – Validate novel markers across primary and metastatic samples within the same patient.

• Clinical translation – Support research aligned with real-world castration-resistant disease.

Applications in Prostate Cancer Research

The CRPC FFPE block pairs are highly versatile:

• Oncology biomarker discovery – Identify molecular drivers of metastasis.

• Drug development – Evaluate new therapies in castration-resistant contexts.

• Pathology education – Train medical professionals using annotated case materials.

• Comparative studies – Contrast IHC, Gleason grades, and treatment responses between primary and metastatic samples.

Quality and Compliance at ArraysBank

ArraysBank ensures every specimen undergoes rigorous multi-layer quality control:

• Ethical and IRB-compliant sourcing

• Pathologist confirmation of tumor type and grade

• H&E and IHC validation to confirm antigenicity

• Controlled storage and FedEx overnight shipping to maintain integrity

Researchers can rely on consistent, reproducible, and well-documented tissue resources.

Conclusion

ArraysBank’s CRPC primary with metastatic FFPE tissue block pairs provide unparalleled value for prostate cancer research. With Gleason scores, Gleason grades, treatment medication history, serum testosterone concentrations, and reference ranges of castration levels, these annotated samples empower investigators to study disease mechanisms, resistance pathways, and potential therapeutic targets.

Explore more about our tissue array and FFPE solutions and discover how ArraysBank can accelerate your prostate cancer research.